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This suggests that ChREBP and downstream associated transcription factors might also play a role in the observed metabolic shift

Irwin, M

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Your Body Needs Time to Adapt Hormonal changes affecting hunger, metabolism, and satiety do not happen instantly

the lactate dyscrasia theory) proposes that mitochondrial dysfunction partly contributes to an accumulation of lactate in the junction of motor neurons and muscle cells (the neuromuscular junction (NMJ)) leading to death of both the nerve and muscle cells, thereby requiring the remaining muscle cells to work harder-than-normal to generate the force necessary for motor control