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For recovery enhancement, performance optimisation, or longevity goals in healthy people, until a randomised, placebo-controlled trial in a defined population with an objective primary endpoint and pharmacovigilance over a clinically meaningful duration produces data we do not currently have, we just don't have good evidence of benefit, let alone safety

However, if someone already has extremely high levels of vitamin B (from taking excessive supplements and showing toxicity symptoms), further pyridoxine would be avoided

Proc Natl Acad Sci (1983) 80:36915

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