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Gila monsters and starving rats: The drugmakers For the generation of biotech executives who presided over the burgeoning industrys first few decades, GLP-1 was the multibillion dollar idea that got away

Prasun P, Ginevic I, Oishi K (2021) Mitochondrial dysfunction in nonalcoholic fatty liver disease and alcohol related liver disease

doi:10.3390/ph18020185

PTX treatment had no effect on the maximum calcium mobilization in response to MDL29,951 (972.4% of the maximum response of the vehicle treatment condition) but was accompanied by a 3-fold shift in the EC 50 of MDL29,951 from 440 nM (pEC 50 = 6.340.06) for vehicle treated to 1300 nM (pEC 50 = 5.890.03) for PTX treated cells, suggesting a role for Gi/o-mediated signaling (Figure 2C)

The diabetes trial added a roughly 2 percent A1C reduction at the top arms, which tells you the glucagon component was not sabotaging glucose control