(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux
The most obvious effect for many people who stop taking GLP-1 drugs is weight regain, as an appetite that once subsided comes roaring back with intensity
People who take this drug can start to lose weight in as little as four weeks, but more research is needed
[1] [4] For patients requiring long-term PPI therapy (beyond 8 weeks) to control reflux symptoms whilst on tirzepatide, review by a gastroenterologist may be appropriate to investigate underlying causes and consider endoscopic evaluation, as recommended in NICE CG184
Refrigerate the vial immediately
Request replacements from your provider as needed