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doi:10.3390/cosmetics2030236 Pickart L, Vasquez-Soltero JM, Margolina A

Others acknowledge that individual variations in MMP expression, copper metabolism, and skin sensitivity can create unexpected reactions

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Clinical validation remains limited because large-scale human trials and regulatory approval are not established

Users of any of these compounds should discuss their use with a physician who can monitor for adverse effects and advise on contraindications including for BPC-157, which carries an unresolved angiogenesis risk that is particularly relevant for individuals with active or suspected cancer