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To circumvent the need for intracellular bioactivation of AQ or DEAQ by CYPs, the toxic effects of the synthetic chemically reactive metabolites AQ-QI and DEAQ-QI were studied

Protein unfolding was monitored by tryptophan fluorescence (ratio 350 nm / 330 nm) during temperature ramping from 25 C to 90 C

Given the enhanced efficacy of the 5FU + metformin combination in AKP organoid models in 3D (Fig

DEEP PENETRATING NEVUS Clinically, deep penetrating nevi can occur de novo as blue papules or nodules, and often they are mistaken for a blue nevus or nodular melanoma