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To further evaluate the effect of increased islet cholesterol content on GLP-1R function, islets isolated from wildtype (WT) mice were loaded with MCD saturated with cholesterol, which led to a significant increase in cholesterol content (Figure 1D)

They are a class of drugs that work on an entirely different biological pathway related to gut hormones, making them a very different and often safer approach for long-term weight management

Excess body fat, particularly around the abdomen, increases insulin resistance

The stomach is a harsh environment filled with acids and enzymes designed to break down proteins