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This can lead to a feeling of being backed up, even if you are eating significantly less than you were before

However, metformin cannot be used in everyone, such as those with a history of lactic acidosis, an estimated glomerular filtration rate (eGFR) 40% [63,64]

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The authors also acknowledge the kind assistance provided by Prof

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After ruling out the pharmaceutical issues above, consider whether biological factors are limiting your response