Because oral supplements are absorbed less effectively, you need to take them far more frequently than you would need an injection
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[1] [3] The standard UK treatment involves hydroxocobalamin 1mg intramuscular injections, with dosing regimens typically consisting of initial loading doses (e.g., every other day for two weeks) followed by maintenance doses every 2-3 months for conditions like pernicious anaemia
This is because though cobalamin will take a couple of weeks to reach appropriate levels in the body, especially if deficient, it can last in the body for a long time once it reaches appropriate concentrations
B12 injections are clinically indicated for specific patient groups with confirmed deficiency or malabsorption conditions
Vitamin B12 Injections may be incompatible with some types of drugs, such as warfarin and certain phenothiazines