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Tesofensine Tesofensine ( NS2330 ) is a serotoninnorepinephrinedopamine reuptake inhibitor from the phenyltropane family of drugs, which is being developed for the treatment of obesity

Tesofensine has a half-life of approximately 60 hours, meaning it takes 1014 days to reach steady-state plasma levels and the same duration to clear after discontinuation

2023 Dec 14;389(24):2221-2232

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[139] Abnormalities in dopaminergic neurotransmission also occur in several painful clinical conditions, including burning mouth syndrome, fibromyalgia, and restless legs syndrome