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Phentermine is typically prescribed for short-term use due to its stimulant properties

Open 6 , e2337799 (2023)

EX-4 stimulates the expression of anti-inflammatory M2 microglial markers (including IL-10, IL-4, arginase 1, and CD206), but not that of proinflammatory M1 markers, which are linked to neuroprotection and antinociception in neuropathic rats [50]

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Participants received once-weekly semaglutide injections or a saline placebo in the randomized, double-blinded study

However, the specific metabolic checkpoints of the altered thresholds need further exploration, which is a future research direction