For further studies, we utilised Gpx4 flox/wt ;Villin-Cre +/ ( Gpx4 +/IEC ) mice 27,28 , which specifically deleted one Gpx4 allele in the intestinal epithelium and resulted in a ~50% reduction of mRNA and protein levels in small and large intestinal IECs (Supplementary Fig
C., Chang, C
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If the short-term approach has already failed you, repeating it is unlikely to produce a different outcome
This is an entirely separate mechanism from its antioxidant properties
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