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Acquired resistance to BET-PROTACs (proteolysis-targeting chimeras) caused by genomic alterations in core components of E3 ligase complexes
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Mechanisms that commonly induce ROS generation in viral infections include the deregulation of mitochondrial function, activation and upregulation of NOX production, and modification of the Nrf2/ARE pathway, with superoxide being the most commonly produced ROS 55
GSH-degrading enzymes are essential for maintaining GSH homeostasis in cells
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