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GIP receptor activation: Augments insulin secretion, promotes adipocyte lipid uptake under fed conditions, and may contribute to central appetite modulation through pathways distinct from GLP-1R
Weight loss itself can improve mental health, and the metabolic improvements from these medications may have neuroprotective benefits
Given similar side effect profiles and the convenience advantage of weekly versus daily dosing, semaglutide has largely superseded liraglutide as the preferred GLP-1 option for most patients
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Episodes of intense flushing and persistent redness are common, and in some cases, individuals may develop rhinophyma, a thickening of the skin on the nose that can be particularly distressing
The trial evaluated once-weekly subcutaneous semaglutide 2.4 mg versus placebo in reducing the risk of MACE (a composite endpoint comprising CV death, nonfatal MI or nonfatal stroke) in individuals with established ASCVD and overweight or obesity but without diabetes
