FDA staff's own briefing document, posted publicly ahead of the meeting as part of the docket, proposes that TB-500 (free base) and TB-500 acetate not be added to the list, citing incomplete physicochemical characterization, a lack of evidence of effectiveness for wound healing (including an in-vitro fibroblast study in which TB-500 reportedly did not induce wound healing), and insufficient nonclinical and clinical safety data
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The peptide promotes collagen synthesis, enhances blood flow to tendons, and improves biomechanical properties
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Nasal sprays are typically easy to use and provide a convenient way to administer TB-500 without the need for injections
This critical distinction allows repeated doses to be drawn safely from the same multi-dose vial without risk of contamination, provided proper aseptic technique is maintained