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When you eat, your body releases GLP-1, which signals the brain to reduce hunger, slows the emptying of the stomach (promoting a feeling of fullness), and stimulates the pancreas to release insulin in response to rising blood sugar

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Each of these drugs slows the processing of food through the digestive tract, which sends messages to patients brains that theyre hungry, resulting in a diminished appetite

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doi: 10.1161/STROKEAHA.112.659656 69 JicklingGCLiuDAnderBPStamovaBZhanXSharpFR

By suppressing appetite and enhancing feelings of fullness, semaglutide GLP-1 can significantly reduce caloric intake and promote weight loss