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The theory described in the peptide literature is that a GHRH analog (signal one) and a ghrelin-receptor agonist (signal two) act in a complementary, even synergistic, way producing a larger GH pulse together than either pathway alone, because the pituitary carries co-receptors for both inputs

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Schumann CM, Bloss CS, Barnes CC, Wideman GM, Carper RA, Akshoomoff N (2010) Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism

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