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The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar in patients with T2D, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke (Fig

However, the exact mechanism behind how GLP-1 medications may reduce Alzheimer's risk is unknown so more research is needed, according to Xu

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Recent studies, including new research published in Nature Medicine (Jan 2025), suggest that these medications carry risks beyond short-term nausea or digestive issues

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