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[1] However, because B12 is water-soluble, the body typically eliminates excess amounts through renal excretion without adverse effects

NICE-recommended weight management strategies include: Dietary intervention aiming for a 600 kcal/day deficit through reduced portion sizes, limiting energy-dense foods, and increasing fruit and vegetable consumption Physical activity building up to 150300 minutes of moderate-intensity aerobic activity weekly, plus muscle-strengthening activities on at least two days weekly, in line with UK Chief Medical Officers' guidelines [10] Behavioural approaches including self-monitoring, goal-setting, and addressing emotional eating patterns Commercial weight management programmes such as those meeting NICE quality standards (QS127) Very-low-calorie diets in specific circumstances, under clinical supervision and for limited periods For patients with a BMI 30 kg/m (or 27.5 kg/m in those of South Asian, Chinese, or other Asian family origin) who have not achieved adequate weight loss through lifestyle measures alone, pharmacological interventions may be considered

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The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists

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Yiyi Xi from the Department of Etiology and Carcinogenesis at Cancer Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College for their early input and efforts during the initial drafting of this manuscript, which helped shape the foundation of this work