We compared the differences in demographic and clinical characteristics between responders and non-responders using Chi-square tests and identified the significant predictors of nonresponse using logistic regression with stepwise selection
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121 Overall, these data accumulate to show that GLP-1 RAs provide not only metabolic and mitochondrial effects but also meaningful clinical impact for vascular and neuroendocrine protection that may ultimately decrease age-related decline in cardiovascular health, musculoskeletal health, and cognitive health
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SystemsAge was calculated using the methylCIPHER package ( The Intrinsic Capacity epigenetic clock was calculated using code available at DNAmFitAge and additional epigenetic metrics were calculated via TruDiagnostics DNAm Analysis Software, available at no cost for research purposes upon request ( access requires agreement to a standard noncommercial software license for academic, nonprofit research use
The pleiotropic effects of glucagon-like peptide-1 receptor agonists in patients with metabolic dysfunction-associated steatohepatitis: a review for gastroenterologists