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During the mean follow-up of approximately 2 years, there were 75 ADRD cases among GLP1RAs users, 639 cases among GLD users, and 101 cases among SGLT2i users

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After numerous manipulations on candidate molecules, one was arrived at that acted as a non-peptide GLP-1 agonist and was given the name orforglipron. Now came the next challenge

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