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The researchers showed that FOXO4-DRI treatment induced apoptosis specifically in senescent chondrocytes while sparing healthy proliferating cells, confirming the selectivity mechanism described in the original Baar et al

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These biofilms protect bacteria from the host immune system as well as antibiotic therapy thereby prolonging their residence on wounds and development of antibiotic resistance (Razdan et al., 2022)

As noted above, these medications are most appropriate in the temporary setting

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