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It is an important water-soluble antioxidant

The inositol requiring enzyme 1 alpha (IRE1) induced thioredoxin-interacting protein (TXNIP)/NLRP3 pathway activation and subsequent pyroptosis have been observed in both HG-exposed NRK-52E cells and diabetic rats (45)

At a later stage, spongiosis and ballooning of keratinocytes are observed (236, 239)

Kundu R, Narean JS, Wang L, Fenn J, Pillay T, Fernandez ND, et al

Stress, chronic illness, and breastfeeding are also common reasons for delayed or missed periods, as they can impact hormonal balance and reproductive health

The primary mechanism involves intrinsic factor binding in the stomach, while a secondary pathway allows small amounts to absorb through passive diffusion