The biologic effects of IGFs signaling on cancer Once activated by the ligands, IGF-IR and InsR may initiate diverse signaling pathways to regulate cell proliferation, differentiation, survival, metabolism, migration, and stemness (Fig
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doi:10.1111/j.1365-2044.2006.04808.x (Letter highlighting the risk of serotonin syndrome with concurrent SSRI and methylene blue, underpinning contraindications and necessary precautions regarding MAO-A inhibition)