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Nausea is the most common, affecting 13-18% in most studies, often during dose escalation

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An increasing body of preclinical and clinical evidence suggests that mitochondrial dysfunction, characterized by bioenergetic failure, heightened oxidative stress, dysregulated calcium handling, and impaired mitophagy, contributes to the etiopathogenesis of both CVDs and cognitive impairment

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A 2026 study published in The Lancet shows similar results