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Unsurprisingly, not every new AOM asset delivered on those expectations in subsequent phase 2 or phase 3 trials, let alone setting ever more spectacular benchmarks for weight loss, while investors increasingly recognised the importance of a clean tolerability profile alongside compelling efficacy [1]

2001;131(3s):1054S-1057S

Conversely, PCD is a genetically regulated and biologically purposeful process, essential for tissue homeostasis, embryonic development, and immune surveillance [10]

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Verma S et al

Embedded within the membrane, these mechano-receptors are pivotal in directing the activation of cardiac fibroblasts and the remodeling of fibrosis, encompassing the regulation of cell proliferation, the promotion of myofibroblast differentiation, the modulation of ECM remodeling, and the facilitation of paracrine signaling pathways[165]