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The group of Gregory Gore described cell death through the mechanism of apoptosis in humans with humans with NASH and successfully introduced the definition of lipotoxicity in patients with NASH [61]
N-acetylcysteine (NAC) has been shown to treat glutathione deficiency 20 in some studies
The mechanism determines whether a hit advances or gets dropped, whether toxicity is on-target or off, and what downstream immune and inflammatory responses to expect
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Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination
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