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As shown in Figures 5D,E and Figure S4C in Supplementary Material, GSTP-S184D performed stronger inhibitory effect on LPS-induced HMGB1 release than GSTP (WT) in primary peritoneal macrophages, and RAW 264.7 and THP-1 cells, but GSTP-S184A showed a smaller influence
Press release, December 11, 2025
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After repeated IM administration of BPC157 at 100 g/kg for seven consecutive days, the plasma concentration versus time curve (Figure 1C) and pharmacokinetic parameters (Table 3) were similar to those observed after a single IM injection at a dose of 100 g/kg, except for a slight increase in C max and AUC 0t
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