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Ketogenesis depends on the transport of long-chain fatty acids, which contain 13 to 21 carbons, into the mitochondria for beta-oxidation (13, 14)

However, the proportion of patients experiencing treatment-emergent adverse events on GLP-1RA as add-on to SGL2i was similar to GLP-1RA only and in line with current literature, with most of them being of mild-to-moderate intensity 39,40

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While direct evidence for brain fog improvement is lacking, several mechanisms suggest GLP-1 medications could theoretically influence cognitive function

Many patients starting semaglutide (Ozempic, Wegovy, Rybelsus) wonder whether their daily coffee habit is compatible with treatment