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The answer affects the likely cause

It combines Vitamin B1 and B12 for a complete fix for certain health issues

The uptake by the liver and kidneys is relatively low

J Med Chem 2017

Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation

Colour is the most immediately useful signal: copper(II) peptide complexes are blue to violet, and the intensity and hue relate to the coordination environment, so a marked change in colour genuinely indicates that something about the complex has altered