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Safety Assessment Acute toxicity A single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice

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Furthermore, since inflammation is associated with the injury or damage of neurons (Yamanouchi et al., 2017), anti-inflammatory danggui Sini decoction could remarkably increase the amounts of Nissl bodies (the biomarker for the normal morphology of neurons) and improve the morphology of DRG cells, thus, alleviating the pathogenesis of peripheral neuropathy (Ding et al., 2020)

Subjective results (sleep, energy, recovery) begin within 2-3 weeks

Through cleavage of dynamic phenylboronic ester bonds under ROS stimulation 62 , the hydrogel demonstrated ROS-sensitive drug release behavior, as evidenced by the 90% cumulative release of D-CuP within 72 h under H 2 O 2 stimulation (Fig