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5 The enzyme TRX reductase maintains TRX in a reduced state (Fig
Composed of 15 amino acids (Gly-Glu-Ser-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu), it is renowned for its exceptional molecular stability, particularly its resistance to enzymatic degradation in various physiological environments
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If glutathione and vitamin C levels are low, this oxidative byproduct can slow down energy production, leading to feelings of fatigue
High-activity inhibitors such as IACS-010759 and BAY87-2243 encountered dose-limiting toxicities during dose-escalation trials, including metabolic acidosis and neurotoxicity, resulting in multiple clinical trial terminations due to narrow therapeutic windows
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