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A: Because it combines GIP, GLP-1, and glucagon agonism in one molecule and keeps producing unusually deep weight-loss results
Data from PIONEER 1 were not included because oral semaglutide was given as monotherapy [12], PIONEER 2 was excluded because all patients randomised to oral semaglutide or comparator were receiving background metformin (and no other background glucose-lowering medication) [13], and PIONEER 6 was excluded because it was a cardiovascular outcomes trial [14]
Semaglutide is a GLP-1 receptor agonist it mimics a gut hormone that signals fullness, slows stomach emptying, and helps regulate blood sugar
PMID: 27789196
Two to three pounds per week is common in the first few months, especially at higher starting weights
This tripeptide exists in reduced (GSH) and oxidized (GSSG) forms, wherein its reduced form readily donates electrons to neutralize harmful free radicals
