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A subsequent study describing the double incretin knock-out (DIRKO) mice showed that male Glp-1r / mice are only mildly glucose intolerant while females exhibited normal glucose tolerance after being backcrossed for five generations onto the C57BL/6 strain [5]

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Oxidative phosphorylation efficiency and ATP production change[8]

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Insulin has returned to baseline, ghrelin is rising, and somatostatin tone is low