Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology
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Upon endocytosis by the endothelial cells, albumin binds to the Fc receptor (FcRn) during endosomal acidification, which sorts the intracellular trafficking of the albumin away from degradative lysosomes and back to the plasma membrane where it can once again reenter the general circulation
doi: 10.1210/en.2012-2124 82 WaserBBlankAKaramitopoulouEPerrenAReubiJC
Lauer ME, Majors AK, Comhair S, Ruple LM, Matuska B, Subramanian A, et al