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Several mechanisms may contribute to the positive effects of GLP1RAs in preventing HF and influencing the outcomes for patients with either HFpEF or HFrEF

Findings GLP-1 RAs exhibit potential beneficial effects on depressive symptoms, cognitive function, and reduced risk of suicidal ideation in animal and human models through antioxidative, anti-inflammatory mechanisms, and modulation of neurotransmitter pathways

KLOW's mechanism as a Klotho mimetic suggests theoretical risks including phosphate dysregulation, hypoglycemia when combined with other glucose-lowering agents, and potential immunogenicity with repeated subcutaneous dosing

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