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Its converted in the body to the active forms methylcobalamin and adenosylcobalamin

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The latest in vitro and in vivo research results show that oxaliplatin-based oxidative stress enhance the phosphorylation level of serine residues of NFS1, which protect CRC cells in an S293 phosphorylation-dependent manner during oxaliplatin treatment (Lin et al., 2022)

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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

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