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As a result of the lack of standardized protocols for developing and assessing asthma models, the lack of high-quality, multi-center studies with large sample sizes is due to the limited size and scope of clinical samples
and as a structural biology ligand, with cryo-EM structures of full-length MC4R in complex with heterotrimeric Gs resolving afamelanotide in the orthosteric pocket alongside alpha-MSH and describing a conserved binding mode for peptidic melanocortin agonists
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Histopathological and hematological assessments were performed in a blinded manner by an independent pathologist/investigator
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