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A metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity to the statin class of host-targeted therapeutics
Cells were washed to remove viral particles and transduced cells were selected in the presence of 1 g/ml puromycin (Sigma-Aldrich, P8833) for at least 96 h
Cheng X et al
10.1172/JCI59755 69 MengX.AnX.ZhouL.FuB.JiaL
Clinical trials involving sulfasalazine combined with radiotherapy for 12 patients with newly diagnosed glioblastoma (NCT 04205357) have shown no significant impact on progression-free survival and overall survival of patients [204]
(PubMed) Ziegler D
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