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By triggering activity of serotonergic neurons in the brain, the drug makes you feel more full and less inclined to desire eating
Most healthcare providers view glutathione as a low-risk supplement, but there is a lack of large-scale clinical trials specifically on pregnant women
The side effect profiles are broadly similar, though individual tolerance varies
CYP3A4 change | Unpredictable trough levels | Major | Measure drug levels q1 to 2 wk during dose escalation | | Levothyroxine | Gastric emptying delay | Reduced Cmax ~30% | Moderate | Administer 60 min before any other oral drug

The most frequently reported adverse effects are gastrointestinal and typically occur during treatment initiation or dose escalation: Nausea (very common): Usually mild to moderate and diminishing over time Diarrhoea (very common): Potentially contributing to dehydration Vomiting (common): Particularly during early treatment phases Constipation (common): Due to delayed gastric emptying Abdominal pain and dyspepsia (common): May affect eating and drinking patterns Decreased appetite (very common): A therapeutic effect that may inadvertently reduce fluid intake Other notable side effects include: Injection site reactions (erythema, pruritus, swelling) Fatigue and dizziness, which may be exacerbated by dehydration Hypoglycaemia, particularly when used with insulin or sulfonylureas (doses of these medications may need to be reduced when starting tirzepatide) Increased heart rate (modest elevation of 2-4 beats per minute) Gallbladder problems including gallstones and inflammation Potential worsening of diabetic retinopathy in patients with pre-existing disease According to NICE guidance , patients should be counselled about these expected side effects before initiating treatment
