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There is no evidence that semaglutide directly reduces the effectiveness of the oral contraceptive pill, though its important to be aware that some side effects could impact the effectiveness of your pill

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48 In the Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (SURMOUNT-5) trial in adult participants with obesity but without T2DM, tirzepatide (10 mg or 15 mg) achieved greater weight loss compared with semaglutide (1.7 mg or 2.4 mg weekly dose): 20.2% (95% CI 21.4 to 19.1) versus -13.7% (95% CI 14.9 to 12.6) at week 72

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