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The experimental protocol was approved by the Institutional Animal Care and Use Committee of Jining Medical University (Approval No

doi: 10.1371/journal.pone.0042529 Summary Keywords cytokine - immunological terms, type 2 diabetes, mycobacteria, oxidative stress, host directed therapy, immune responses Citation To K, Cao R, Yegiazaryan A, Owens J, Nguyen T, Sasaninia K, Vaughn C, Singh M, Truong E, Medina A, Avitia E, Villegas J, Pham C, Sathananthan A and Venketaraman V (2021) Effects of Oral Liposomal Glutathione in Altering the Immune Responses Against Mycobacterium tuberculosis and the Mycobacterium bovis BCG Strain in Individuals With Type 2 Diabetes

In addition to the rapid epigenetic modulation of glutamatergic function, preclinical studies showed that boosting mitochondrial metabolism of LAC protects against oxidative stress, rapidly ameliorates insulin resistance, and reduces neuroinflammation by decreasing proinflammatory pathways such as NFkB in hippocampal and cortical neurons

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