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Retatrutide is a triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, whereas semaglutide acts on GLP-1 receptors alone and tirzepatide targets both GIP and GLP-1 receptors
Publication bias was minimised by comprehensive literature searching
A 2025 study in BMC Medicine found that within just eight weeks of stopping anti-obesity medications (AOMs), participants experienced significant weight regain compared to those who continued treatment
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Int J Mol Sci 13(10):1262912655
PMID: 26771670 Choules MP, et al
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