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Mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) overexpression is associated with tumor cell proliferation and is a novel target for drug development

It is being studied in models of rheumatoid arthritis, COPD, Crohn's disease, and pulmonary fibrosis.Delgado et al., Pharmacol Rev 2004)

The peptide retains activity in human gastric juice for more than 24 hours, tolerates pH from 1 to 11, and resists multiple proteolytic enzymes, properties that derive from the high proline content (four of fifteen residues) and the absence of cleavage-prone motifs

Regulation of GSH Synthesis: Nrf2, a Vital Player GSH synthesis in the cells is highly dependent on the expression and the activity of GCS

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5 mg vial + 2 mL BAC water: Concentration = 2,500 mcg/mL 250 mcg dose = 10 units (0.1 mL) on a 100-unit insulin syringe 500 mcg dose = 20 units (0.2 mL) on a 100-unit insulin syringe Doses per vial: 20 doses at 250 mcg, or 10 doses at 500 mcg Supplies Needed (8-Week Cycle at 250 mcg/day) 3 vials BPC-157 (5 mg each) provides 60 doses, covers 56 days with margin 3 vials bacteriostatic water (30 mL each) 60 insulin syringes (2931 gauge, 100-unit) Alcohol prep pads Administration Injection Technique BPC-157 goes subcutaneous (SubQ)