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Studies in metabolic syndrome and obesity models show that low IGF-1 levels correlate with dysregulated lipid metabolism, increased visceral adiposity, and impaired insulin sensitivity
Some patients tolerate the oral formulation better because it bypasses the rapid systemic absorption that triggers severe nausea
Diabetes Obes Metab (2016) 18:4919
Gastroparesis treatments can include: medications to stimulate stomach muscles and nerves to allow stomach to empty, medications to control vomiting or nausea, medications to relieve pain, medications to treat heartburn, medications to manage blood sugar, gastric bypass surgery (including a partial gastrectomy to remove or close off part of the stomach and gastrojejunostomy to place a feeding tube in the small intestine (jejunostomy tube) to connect the stomach to the middle part of the small intestine (jejunum) while bypassing the first part (duodenum), surgery to place a gastric venting tube to relieve pressure, a pyloroplasty (to relax and expand the muscular valve (pylorus) at the bottom of the stomach that empties food out of it), a gastric peroral endoscopic myotomy (G-POEM), nutritional/diet therapy to make sure the body has sufficient nutrition and is hydrated, among other treatments
