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Quick Answer: Tirzepatide burns fat primarily by reducing appetite and caloric intake through dual GIP and GLP-1 receptor activation, creating an energy deficit that promotes fat mobilization and oxidation

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Because it is selective for the GLP-1 receptor, it functions in comparative work as the reference point against which dual and triple agonists are measured: an effect that semaglutide reproduces is a GLP-1-receptor effect, and an effect it does not reproduce is evidence that a second or third receptor is doing something

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