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Five different GLP-1 agonists have been FDA-approved, and doctors have focused mainly on one tirzepitide (Zepbound/Mounjaro)

In clinical trials of Liraglutide (1.8 mg) and Albiglutide (50 mg), liraglutide was superior for reducing HbA1c, but was more likely to lose weight in patients

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Furthermore, the expression of Col5a1 was increased in Glp1r VSM/ kidney and renal artery compared with Glp1r VSM+/+ tissue (Supplemental Figure 4, H and K)

J Endocrinol Metab 11(5):95107 Liu Y et al (2023) The weight-loss effect of GLP-1RAs glucagon-like peptide-1 receptor agonists in non-diabetic individuals with overweight or obesity: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials