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Ethics statement The studies involving humans were approved by Slovenian National Medical Ethics Committee (approval number 0120-258/2019/12)

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Some studies have suggested that the proliferation and apoptosis of granulosa cells (GCs) are the root causes of follicular development and atresia, with forkhead box protein O1 (FoxO1) playing an important role in promoting PCOS follicular atresia and GCs apoptosis (162, 163)

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No published Phase I trial establishing tolerability, human pharmacokinetics or dose escalation was identified

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Knowing the key differences between semaglutide and tirzepatide is important for anyone who wants to switch between these medicines

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The first 12 weeks are often viewed as an early response period

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