95(3): p
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For quantitative assessment of Nrf2 translocation from the cytosol to the nucleus, an automated Cellomics ArrayScan (Thermo Fisher) microscope system was employed
Clinical studies in humans have not been published so far ( Development, preclinical, and early clinical data on the GIP/GLP-1 receptor agonist tirzepatide Among the GIP/GLP-1 receptor agonists, tirzepatide (LY3298176) is the compound that is the most advanced in development and the first substance in this class that has received approval for the therapy of T2D by the FDA in May 2022 (manufacturer Eli Lilly Comp., trade name Mounjaro ) ( Pharmacodynamics Tirzepatide is a GIP/GLP-1 chimeric peptide with a peptide chain length of 39 amino acids
It promotes weight loss by enhancing insulin response and slowing digestion
In addition, administration of the drug in a thrombotic mouse model revealed a significant decrease in the area of cerebral edema, the area of cerebral infarction, and the expression of pro-inflammatory factors in mice (Keuters et al., 2021)