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This extended duration is what allows it to be administered as a once-weekly injection

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The body appears to adapt to both the delayed gastric emptying effects and the central nervous system appetite-suppressing signals, resulting in reduced nausea, vomiting, and other GI symptoms even as doses increase to therapeutic levels

Consequently, manipulating the effects of GLP-1 has been seen as having interesting potential as a therapeutic target in type 2 diabetes

Safety & Human Experience While large-scale clinical trials are pending, human research subjects and real-world users have reported significant improvements in ulcer healing, reflux symptoms, and gut discomfort sometimes in as little as one week

Per FDA labeling, if intolerable side effects occur, consider delaying dose escalation or reverting to a prior dose